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David B. Shackelford

University of California, Los Angeles

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Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer

2021 Cold Spring Harbor Perspectives in Medicine
- Gina M. DeNicola
- David B. Shackelford
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Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-deficient Non-Small Cell Lung Cancer.

2021 Cancer Research
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Abstract 1572: Broad glutamine pathway inhibition by DRP-104 results in anti-tumor activity in hypermetabolic lung tumors resistant to PD-1 or osimertinib therapy

2021 Immunology
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Abstract 2818: In vivo imaging of mitochondrial bioenergetics in lung cancer

2021 Tumor Biology
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Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden.

2021 Cancer Immunology, Immunotherapy
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Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.

2021 Chemistry & Biology
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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.

2021 Nature Communications
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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.

2021 Cell Metabolism
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Abstract A46: A novel patient-derived approach for preclinical evaluation of predictive imaging biomarkers in early lung cancer

2020 Cancer Research
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A Phase 1 Trial of MLN0128 (sapanisertib) and CB-839 HCl (telaglenastat) in Advanced NSCLC Patients (NCI 10327): Rationale and Study Design

2020 Clinical Lung Cancer
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