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L. Mark Fisher

St George's Hospital
St George's, University of London

45

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1923

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Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.

2021 Journal of Medicinal Chemistry
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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.

2020 Journal of Medicinal Chemistry
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Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase

2018 Nature Communications
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Studies of prokaryotic Type II topoisomerase drug inhibition

2017 Acta Crystallographica Section A
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Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.

2016 Open Biology
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Type II topoisomerases as targets for rational drug design

2014 Acta Crystallographica Section A
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Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases

2013 Nucleic Acids Research
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Insights into the mechanism for DNA capture and transport by topoisomerase II provided by the high-resolution structure of an 'open' topoisomerase II-DNA complex

2013 Acta Crystallographica Section A
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Structure of an ‘open’ clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

2013 Nucleic Acids Research
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Correction: Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

2010 PLOS ONE
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Citations (17)