Thyroid hormone receptor alpha

1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX706721833ENSG00000126351ENSMUSG00000058756P10827P63058NM_199334NM_001190918NM_001190919NM_003250NM_178060NM_001313983NP_001177847NP_001177848NP_003241NP_955366NP_001300912NP_835161Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.1nav: Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta12h77: Crystal structure of human TR alpha bound T3 in monoclinic space group2h79: Crystal Structure of human TR alpha bound T3 in orthorhombic space group Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. THR1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.