Factor X

1C5M, 1EZQ, 1F0R, 1F0S, 1FAX, 1FJS, 1G2L, 1G2M, 1HCG, 1IOE, 1IQE, 1IQF, 1IQG, 1IQH, 1IQI, 1IQJ, 1IQK, 1IQL, 1IQM, 1IQN, 1KSN, 1LPG, 1LPK, 1LPZ, 1LQD, 1MQ5, 1MQ6, 1NFU, 1NFW, 1NFX, 1NFY, 1P0S, 1V3X, 1WU1, 1XKA, 1XKB, 1Z6E, 2BMG, 2BOH, 2BOK, 2BQ6, 2BQ7, 2BQW, 2CJI, 2D1J, 2EI6, 2EI7, 2EI8, 2FZZ, 2G00, 2GD4, 2H9E, 2J2U, 2J34, 2J38, 2J4I, 2J94, 2J95, 2JKH, 2P16, 2P3F, 2P3T, 2P3U, 2P93, 2P94, 2P95, 2PHB, 2PR3, 2Q1J, 2RA0, 2UWL, 2UWO, 2UWP, 2VH0, 2VH6, 2VVC, 2VVU, 2VVV, 2VWL, 2VWM, 2VWN, 2VWO, 2W26, 2W3I, 2W3K, 2WYG, 2WYJ, 2XBV, 2XBW, 2XBX, 2XBY, 2XC0, 2XC4, 2XC5, 2Y5F, 2Y5G, 2Y5H, 2Y7X, 2Y7Z, 2Y80, 2Y81, 2Y82, 3CEN, 3CS7, 3ENS, 3FFG, 3HPT, 3IIT, 3K9X, 3KL6, 3Q3K, 3SW2, 3TK5, 3TK6, 4A7I, 3KQB, 3KQC, 3KQD, 3KQE, 3LIW, 3M36, 3M37, 4BTI, 4BTT, 4BTU, 4Y6D, 4Y71, 4Y76, 4Y79, 4Y7A, 4Y7B, 4ZHA, 4ZH8, 5K0H215914058ENSG00000126218ENSMUSG00000031444P00742O88947NM_000504NM_001312674NM_001312675NM_001242368NM_007972NP_000495NP_001299603NP_001299604NP_001229297NP_031998Factor X, also known by the eponym Stuart–Prower factor, is an enzyme (EC 3.4.21.6) of the coagulation cascade. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.1c5m: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR1ezq: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR1285151f0r: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2088151f0s: Crystal Structure of Human Coagulation Factor XA Complexed with RPR2087071fax: COAGULATION FACTOR XA INHIBITOR COMPLEX1fjs: CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA1g2l: FACTOR XA INHIBITOR COMPLEX1g2m: FACTOR XA INHIBITOR COMPLEX1hcg: STRUCTURE OF HUMAN DES(1-45) FACTOR XA AT 2.2 ANGSTROMS RESOLUTION1ioe: Human coagulation factor Xa in complex with M555321iqe: Human coagulation factor Xa in complex with M555901iqf: Human coagulation factor Xa in complex with M551651iqg: Human coagulation factor Xa in complex with M551591iqh: Human coagulation factor Xa in complex with M551431iqi: Human coagulation factor Xa in complex with M551251iqj: Human coagulation factor Xa in complex with M551241iqk: Human coagulation factor Xa in complex with M551131iql: Human coagulation factor Xa in complex with M544761iqm: Human coagulation factor Xa in complex with M544711iqn: Human coagulation factor Xa in complex with M551921ksn: Crystal Structure of Human Coagulation Factor XA Complexed with FXV6731kye: Factor Xa in complex with (R)-2-(3-adamantan-1-yl-ureido)-3-(3-carbamimidoyl-phenyl)-N-phenethyl-propionamide1lpg: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79.1lpk: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.1lpz: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41.1lqd: CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45.1mq5: Crystal Structure of 3-chloro-N-carbonyl]phenyl]-4--2-thiophenecarboxamide Complexed with Human Factor Xa1mq6: Crystal Structure of 3-chloro-N-carbonyl]-6-methoxyphenyl]-4-methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa1nfu: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR1327471nfw: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2096851nfx: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2089441nfy: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR2000951p0s: Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R1v3x: Factor Xa in complex with the inhibitor 1- carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine1wu1: Factor Xa in complex with the inhibitor 4--2-(2-methylpropyl)-1-carbonyl]piperazine1xka: FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID1xkb: FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID1z6e: Crystal Structure of Factor Xa complexed to Razaxaban2bmg: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 502boh: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND ''1''2bok: FACTOR XA - CATION2bq6: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 212bq7: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 432bqw: CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 452cji: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2d1j: Factor Xa in complex with the inhibitor 2-piperazin-1-yl] carbonyl]thienopyridine n-oxide2fzz: Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolopyridin-7-one2g00: Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolopyridin-1-yl)benzamide2gd4: Crystal Structure of the Antithrombin-S195A Factor Xa-Pentasaccharide Complex2h9e: Crystal Structure of FXa/selectide/NAPC2 ternary complex2j2u: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j34: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j38: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j4i: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j94: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2j95: CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX2uwl: SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA2uwo: SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA2uwp: FACTOR XA INHIBITOR COMPLEX Factor X, also known by the eponym Stuart–Prower factor, is an enzyme (EC 3.4.21.6) of the coagulation cascade. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis. Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Xase). It is therefore the first member of the final common pathway or thrombin pathway. It acts by cleaving prothrombin in two places (an arg-thr and then an arg-ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex. Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis.