PUM1

1IB2, 1M8W, 1M8X, 1M8Y, 1M8Z, 2YJY, 3BSB, 3BSX, 3Q0L, 3Q0M, 3Q0N, 3Q0O, 3Q0P969880912ENSG00000134644n/aQ14671Q80U78NM_014676NM_001020658NM_001159603NM_001159604NM_001159605NM_001159606NM_030722NP_001018494NP_055491NP_001343493NP_001343494NP_001343495Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.1ib2: CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN1m8w: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-19 RNA1m8x: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA1m8y: CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE2-10 RNA1m8z: Crystal Structure Of A Pumilio-Homology Domain Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene. This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.