CACNA2D1

78112293ENSG00000153956ENSMUSG00000040118P54289O08532NM_000722NM_001302890NM_001366867NM_001110843NM_001110844NM_001110845NM_001110846NM_009784NP_000713NP_001289819NP_001353796NP_001104313NP_001104314NP_001104315NP_001104316NP_033914Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene. Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene. This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. alpha2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain. This article incorporates text from the United States National Library of Medicine, which is in the public domain.