A hyaline substance is one with a glassy appearance. The word is derived from Greek: ὑάλινος transparent and Greek: ὕαλος crystal, glass. A hyaline substance is one with a glassy appearance. The word is derived from Greek: ὑάλινος transparent and Greek: ὕαλος crystal, glass. In histopathological medical usage, a hyaline substance appears glassy and pink after being stained with haematoxylin and eosin—usually it is an acellular, proteinaceous material. An example is hyaline cartilage, a transparent, glossy articular joint cartilage.