Follistatin

3HH2, 2B0U, 2P6A1046814313ENSG00000134363ENSMUSG00000021765P19883P47931NM_006350NM_013409NM_008046NM_001301373NM_001301375NP_006341NP_037541NP_001288302NP_001288304NP_032072Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.1lr8: Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)2p6a: The structure of the Activin:Follistatin 315 complex1lr7: Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (SOS)2arp: Activin A in complex with Fs12 fragment of follistatin1lr9: STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN2b0u: The Structure of the Follistatin:Activin Complex Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals. Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone. An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).