HOXD10

323615430ENSG00000128710ENSMUSG00000050368P28358P28359NM_002148NM_013554NP_002139NP_038582Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b. This article incorporates text from the United States National Library of Medicine, which is in the public domain.