XPO1

1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS7514103573ENSG00000082898ENSMUSG00000020290O14980Q6P5F9NM_003400NM_001035226NM_134014NP_003391NP_001030303NP_598775Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of proteins, rRNA, snRNA, and some mRNA.1w9c: PROTEOLYTIC FRAGMENT OF CRM1 SPANNING SIX C-TERMINAL HEAT REPEATS Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of proteins, rRNA, snRNA, and some mRNA. XPO1 (CRM1) originally was identified in the fission yeast Schizosaccharomyces pombe in a genetic screen, and investigators determined that it was involved in control of the chromosome structure Exportin 1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically mediates the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MAPK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. XPO1 has been shown to interact with: