Sitagliptin/metformin

Sitagliptin/metformin, sold under the brand name Janumet among others, is a combination medication used to treat type 2 diabetes. It may be used in those whose blood sugar is not controlled with metformin and a sulfonylurea. It is taken by mouth. Sitagliptin/metformin, sold under the brand name Janumet among others, is a combination medication used to treat type 2 diabetes. It may be used in those whose blood sugar is not controlled with metformin and a sulfonylurea. It is taken by mouth. Common side effects include diarrhea, headache, and upper respiratory tract infections. Serious side effects may include lactic acidosis, pancreatitis, low blood sugar, heart failure, joint pain, and allergic reactions. It has not been properly studied in people who are pregnant or breastfeeding. It contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide). The combination was approved for medical use in the United States in 2007. A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019. In the United States the wholesale cost of this amount is about 433 USD. In 2016 it was the 191st most prescribed medication in the United States with more than 3 million prescriptions. As of 2018 the combination was marketed under several brand names, including Efficib, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, and Velmetia. A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019. In the United States the wholesale cost of this amount is about 433 USD. In Denmark 100 tablets (each 1,000 mg) cost over the counter in a pharmacy DKK 62.60 = US$ 9.40 = £7.50, thus a month supply in Denmark costs DKK 37.50 = US$ 5.70 = £ 4.50. The pharmacy buys wholesale at DKK 33.83 = US$ 5.11 = £4.10.