IRF3

3QU6, 1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 5JEO, 5JEK, 5JER, 5JEM, 5JEL, 5JEJ366154131ENSG00000126456ENSMUSG00000003184Q14653P70671NM_001197127NM_001197128NM_001571NM_016849NP_001184056NP_001184057NP_001562NP_001184053.1NP_001184056.1NP_001184057.1NP_058545Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.1j2f: X-ray crystal structure of IRF-3 and its functional implications1qwt: Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain1t2k: Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA1zoq: IRF3-CBP complex Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. IRF3 plays an important role in the innate immune system's response to viral infection. Aggregated MAVS have been found to activate IRF3 dimerization. A recent study shows phosphorylation of innate immune adaptor proteins MAVS, STING and TRIF at a conserved pLxIS motif recruits and specifies IRF3 phosphorylation and activation by the Serine/threonine-protein kinase TBK1, thereby activating the production of type-I interferons. Another study has shown that IRF3-/- knockouts protect from myocardial infarction. The same study identified IRF3 and the type I IFN response as a potential therapeutic target for post-myocardial infarction cardioprotection. IRF3 has been shown to interact with IRF7.