Piplartine

Piperlongumine (PL) is a natural product constituent of the fruit of the Long pepper (Piper longum), a pepper plant found in southern India and southeast Asia. Piperlongumine (PL) is a natural product constituent of the fruit of the Long pepper (Piper longum), a pepper plant found in southern India and southeast Asia. Piperlongumine may have anti-cancer properties. In in vitro experiments, it selectively kills some types cancer cells over normal cells. One study in a xenograft mouse model of cancer showed that piperlongumine inhibits the growth of malignant breast tumors and their associated metastases. Although this study has been retracted . Its anticancer effects may be due to silencing the GSTP1 gene. Piperlongumine inhibits the migration of breast cancer cells (MDA-MB-231), an approach for discovering antimetastatic agents. Some piperlongumine derivatives were potent anti-inflammatory agents. The synthesis typically involved Schotten-Baumann reaction between the acid chloride of 3,4,5-trimethoxycinnamic acid with the corresponding amines. Wang et al., evaluated piperlongumine as a novel senolytic agent.