GRIK1

2ZNS, 2ZNT, 2ZNU, 3FUZ, 3FV1, 3FV2, 3FVG, 3FVK, 3FVN, 3FVO, 4MF3289714805ENSG00000171189ENSMUSG00000022935P39086Q60934NM_001320630NM_001330993NM_001330994NM_010348NM_146072NM_001346964NP_001317922NP_001317923NP_783300n/aGlutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene.1txf: CRYSTAL STRUCTURE OF THE GLUR5 LIGAND BINDING CORE IN COMPLEX WITH GLUTAMATE AT 2.1 ANGSTROM RESOLUTION1ycj: Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate2f34: Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution2f35: Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution2f36: Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution2ojt: Structure and mechanism of kainate receptor modulation by anions Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene. This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as a ligand-gated ion channel. The specific GluR subunit encoded by this gene is of the kainate receptor subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. Two alternatively spliced transcript variants that encode different isoforms have been described. Exons of this gene are interspersed with exons from the C21orf41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein. GRIK1 has been shown to interact with DLG4, PICK1 and SDCBP.