Eosinophil-derived neurotoxin

1GQV, 1HI2, 1HI3, 1HI4, 1HI5, 1K2A, 2BEX, 2BZZ, 2C01, 2C02, 2C05, 5E13603654159ENSG00000169385ENSMUSG00000059606P10153O35292NM_002934NM_019398NP_002925NP_062271Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.1gqv: ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN1hi2: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) - SULPHATE COMPLEX1hi3: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-2'-5'-DIPHOSPHATE COMPLEX1hi4: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-3'-5'-DIPHOSPHATE COMPLEX1hi5: EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-5'-DIPHOSPHATE COMPLEX1k2a: Modified Form of Eosinophil-derived Neurotoxin2bex: CRYSTAL STRUCTURE OF PLACENTAL RIBONUCLEASE INHIBITOR IN COMPLEX WITH HUMAN EOSINOPHIL DERIVED NEUROTOXIN AT 2A RESOLUTION2bzz: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A2c01: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A2c02: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A2c05: CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene. The protein encoded by this gene is found in eosinophil granulocytes. It is closely related to the eosinophil cationic protein (RNASE3) from which it diverged ~50 million years ago after the split between the old world and the new world monkeys. It is relatively neutral and has cytotoxic properties. It is capable of reducing the activity of single strand RNA viruses in culture through its enzymatic activity. It also serves as an attractant to immune cells.