Trichodiene synthase

In enzymology, a trichodiene synthase (EC 4.2.3.6) is an enzyme that catalyzes the chemical reaction In enzymology, a trichodiene synthase (EC 4.2.3.6) is an enzyme that catalyzes the chemical reaction Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, trichodiene and diphosphate. This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis. As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1YJ4, 1YYQ, 1YYR, 1YYS, 1YYT, 1YYU, 2AEK, 2AEL, and 2AET.