CEP170

4JON9859545389ENSG00000143702ENSG00000276725ENSMUSG00000057335Q5SW79Q6A065NM_001042404NM_001042405NM_014812NM_001024722NM_001099637NM_001368872NM_001368873NP_001035863NP_001035864NP_055627NP_001093107NP_001355801NP_001355802Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene. Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene. The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1) and polo-like kinase 1 ( PLK1), and functions in maintaining Microtubule organization, cell morphology and cilium stability. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.