Polyamine

A polyamine is an organic compound having more than two amino groups. Alkyl polyamines occur naturally but are also synthetic. Alkylpolyamines are colorless, hygroscopic, and water soluble. Near neutral pH, they exist as the ammonium derivatives. Most aromatic polyamines are crystalline solids at room temperature.spermidinespermineTris(2-aminoethyl)amineCyclen1,4,7-Triazacyclononane1,1,1-Tris(aminomethyl)ethaneSubunit of polyethylenimine A polyamine is an organic compound having more than two amino groups. Alkyl polyamines occur naturally but are also synthetic. Alkylpolyamines are colorless, hygroscopic, and water soluble. Near neutral pH, they exist as the ammonium derivatives. Most aromatic polyamines are crystalline solids at room temperature. Low-molecular-weight linear polyamines are found in all forms of life. The principal examples are the triamine and tetraamine spermidine and spermine. They are structurally and biosynthetically related to the diamines putrescine and cadaverine. Polyamine metabolism is regulated by the activity of the enzyme ornithine decarboxylase (ODC). Polyamines are found in high concentrations in the mammalian brain. Several synthetic polyamines are used in chemical industry and the research laboratory. They are mainly of interest as additives to motor oil and as co-reactants (hardeners) with epoxy resins. Many synthetic polyamines feature NCH2CH2N linkages: Polyethylene amine is a polymer derived from aziridine. Although it is known that the biosynthesis of polyamines is highly regulated, the biological function of polyamines is only partly elucidated. In their cationic ammonium form, they bind to DNA, and, in structure, they represent compounds with cations that are found at regularly spaced intervals (unlike, say, Mg2+ or Ca2+, which are point charges). They have also been found to act as promoters of programmed ribosomal frameshifting during translation. Inhibition of polyamine biosynthesis, retards or stops cell growth. The provision of exogenous polyamines restores the growth of these cells. Most eukaryotic cells have a polyamine transporter system on their cell membrane that facilitates the internalization of exogenous polyamines. This system is highly active in rapidly proliferating cells and is the target of some chemotherapeutics currently under development. Polyamines are also modulators of a variety of ion channels, including NMDA receptors and AMPA receptors. They block inward-rectifier potassium channels so that the currents of the channels are inwardly rectified, thereby the cellular energy, i.e. K+ ion gradient across the cell membrane, is conserved. In addition, polyamine participate in initiating the expression of SOS response of Colicin E7 operon and down-regulate proteins that are essential for colicin E7 uptake, thus conferring a survival advantage on colicin-producing E. coli under stress conditions. Polyamines can enhance the permeability of the blood–brain barrier. They are involved in modulating senescence of organs in plants and are therefore considered as a plant hormone. In addition, they are directly involved in regulation of programmed cell death