In mathematics, in the area of complex analysis, the general difference polynomials are a polynomial sequence, a certain subclass of the Sheffer polynomials, which include the Newton polynomials, Selberg's polynomials, and the Stirling interpolation polynomials as special cases. In mathematics, in the area of complex analysis, the general difference polynomials are a polynomial sequence, a certain subclass of the Sheffer polynomials, which include the Newton polynomials, Selberg's polynomials, and the Stirling interpolation polynomials as special cases.