Silicone-induced granuloma

Silicone granulomas are a skin condition that occur as a reaction to liquid silicones, and are characterized by the formation of nodules.:46 Silicone granulomas are a skin condition that occur as a reaction to liquid silicones, and are characterized by the formation of nodules.:46 Formation of a granuloma is a common tissue response to a range of foreign bodies. Silicone can be directly injected into tissue as part of a cosmetic procedure or it can leak from silicone implants. The formation and consequences of silicon-induced granulomas is not well described or understood. The extent of damage that they cause is controversial. Silicone-induced granuloma can be associated with fever, calcitriol-mediated hypercalcemia, reactive amyloidosis.