MAPK10

1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L, 4X21560226414ENSG00000109339ENSMUSG00000046709P53779Q499Y8Q61831NM_001318068NM_001318069NM_001351624NM_001351625NM_001363657NM_001318102NM_001318131NP_620448NP_001338553NP_001338554NP_001350586NP_001304997.1NP_001305060NP_033184Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP6001251uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP6001252b1p: inhibitor complex of JNK32exc: Inhibitor complex of JNK32g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6--4,5,6,7-tetrahydrothienopyridin-2-yl}-1-naphthalenecarboxamide2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. MAPK10 has been shown to interact with MAPK8IP3.