2-Aminoindane

2-Aminoindane (2-AI) is a research chemical and drug with applications in neurologic disorders and psychotherapy. It is also a drug of abuse as a component of some bath salts, with potential for neurotoxicity and brain damage. 2-Aminoindane (2-AI) is a research chemical and drug with applications in neurologic disorders and psychotherapy. It is also a drug of abuse as a component of some bath salts, with potential for neurotoxicity and brain damage. Synthetic aminoindanes were originally developed in the context of anti-Parkinsonian drugs as a metabolite of rasagiline and as a tool to be used in psychotherapy. They are also commonly abused in the form of bath salts and widely substituted for ecstasy. Having a serotonergic mechanism, there is concern about risk for serotonin syndrome with their abuse. Deaths related to their toxic effects have been observed both in the laboratory in animal studies and in clinical encounters. 2-AI is a rigid analogue of amphetamine and partially substitutes for it in rat discrimination tests. There are a number of derivatives of 2-aminoindane and its positional isomer 1-aminoindane exist, including: As of October 2015 2-AI is a controlled substance in China. 2-Aminoindane is not scheduled at the federal level in the United States, but may be considered an analog of amphetamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.