language-icon Old Web
English
Sign In

Pathogenesis

The pathogenesis of a disease is the biological mechanism (or mechanisms) progress of disease showing its morphological features or that leads to the diseased state. The term can also describe the origin and development of the disease, and whether it is acute, chronic, or recurrent. The word comes from the Greek πάθος pathos ('suffering', 'disease') and γένεσις genesis ('creation'). The pathogenesis of a disease is the biological mechanism (or mechanisms) progress of disease showing its morphological features or that leads to the diseased state. The term can also describe the origin and development of the disease, and whether it is acute, chronic, or recurrent. The word comes from the Greek πάθος pathos ('suffering', 'disease') and γένεσις genesis ('creation'). Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. For example, bacterial pathogenesis is the mechanism by which bacteria cause infectious illness. Most diseases are caused by multiple processes. For example, certain cancers arise from dysfunction of the immune system (skin tumors and lymphoma after a renal transplant, which requires immunosuppression). The pathogenic mechanisms of a disease (or condition) are set in motion by the underlying causes, which if controlled would allow the disease to be prevented. Often, a potential cause is identified by epidemiological observations before a pathological link can be drawn between the cause and the disease. The pathological perspective can be directly integrated into an epidemiological approach in the interdisciplinary field of molecular pathological epidemiology. Molecular pathological epidemiology can help to assess pathogenesis and causality by means of linking a potential risk factor to molecular pathologic signatures of a disease. Thus, the molecular pathological epidemiology paradigm can advance the area of causal inference.

[ "Diabetes mellitus", "Disease", "Internal medicine", "Pathology", "Immunology", "Human gammaherpesvirus", "Murine Acquired Immunodeficiency Syndrome", "Neurofibrillary tangle formation", "Simian varicella virus", "KRIT1 gene" ]
Parent Topic
Child Topic
    No Parent Topic