Arrestin beta 1

2IV8408109689ENSG00000137486ENSMUSG00000018909P49407Q8BWG8NM_004041NM_020251NM_177231NM_178220NP_004032NP_064647NP_796205NP_835738Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.1g4m: CRYSTAL STRUCTURE OF BOVINE BETA-ARRESTIN 11g4r: CRYSTAL STRUCTURE OF BOVINE BETA-ARRESTIN 11jsy: Crystal structure of bovine arrestin-21zsh: Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6) Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.Beta-arrestin might also play a role as scaffold protein in the GPCR pathways. Arrestin beta 1 has been shown to interact with