Arachidonyl trifluoromethyl ketone

Arachidonyl trifluoromethyl ketone (ATK) is an analog of arachidonic acid. that inhibits some isoforms of the enzyme phospholipase A2. Specifically it inhibits the 85 kDa cystolic PLA2 (cPLA2). Arachidonyl trifluoromethyl ketone (ATK) is an analog of arachidonic acid. that inhibits some isoforms of the enzyme phospholipase A2. Specifically it inhibits the 85 kDa cystolic PLA2 (cPLA2). It has been studied as a neuroprotective agent after spinal cord injury, and in animal models of multiple sclerosis.