RGS4

599919736ENSG00000117152ENSMUSG00000038530P49798O08899NM_001102445NM_001113380NM_001113381NM_005613NM_009062NP_001095915NP_001106851NP_001106852NP_005604NP_005604.1NP_033088Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling.1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS41ezt: HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR1ezy: HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling. Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain which conveys GAP activity. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. A number of studies associate the RGS4 gene with schizophrenia, while some fail to detect an association. RGS4 is also of interest as one of the three main RGS proteins (along with RGS9 and RGS17) involved in terminating signalling by the mu opioid receptor, and may be important in the development of tolerance to opioid drugs. RGS4 has been shown to interact with: