Sunset Yellow FCF

Sunset Yellow FCF (also known as Orange Yellow S, or C.I. 15985) is a petroleum-derived orange azo dye with a pH dependent maximum absorption at about 480 nm at pH 1 and 443 nm at pH 13 with a shoulder at 500 nm.:463 When added to foods sold in the US it is known as FD&C Yellow 6; when sold in Europe, it is denoted by E Number E110. Sunset Yellow FCF (also known as Orange Yellow S, or C.I. 15985) is a petroleum-derived orange azo dye with a pH dependent maximum absorption at about 480 nm at pH 1 and 443 nm at pH 13 with a shoulder at 500 nm.:463 When added to foods sold in the US it is known as FD&C Yellow 6; when sold in Europe, it is denoted by E Number E110. Sunset Yellow is used in food, cosmetics, and drugs.:4 For example, it is used in candy, desserts, snacks, sauces, and preserved fruits.:463–465Sunset Yellow is often used in conjunction with E123, amaranth, to produce a brown colouring in both chocolates and caramel. The acceptable daily intake (ADI) is 0–4 mg/kg under both EU and WHO/FAO guidelines.:465Sunset Yellow FCF has no carcinogenicity, genotoxicity, or developmental toxicity in the amounts at which it is used.:465 It has been claimed since the late 1970s under the advocacy of Benjamin Feingold that Sunset Yellow FCC causes food intolerance and ADHD-like behavior in children but there is no scientific evidence to support these broad claims.:452 It is possible that certain food coloring may act as a trigger in those who are genetically predisposed, but the evidence is weak. Sunset Yellow FCF was banned or restricted around year 2000 as a food additive in Norway, Finland and Sweden. In 2008, the Food Standards Agency of the UK called for food manufacturers to voluntarily stop using six food additive colours, Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow and Carmoisine (dubbed the 'Southampton 6') by 2009, and provided a document to assist in replacing the colors with other colors. An EU regulation came into effect in 2010 mandating that food manufacturers include a label on foods containing the Southampton 6 stating: 'may have an adverse effect on activity and attention in children'. Sunset Yellow FCF is known as FD&C Yellow No. 6 in the US and is approved for use in coloring food, drugs, and cosmetics with an acceptable daily intake of 3.75 mg/kg.:2,7 Since the 1970s and the well-publicized advocacy of Benjamin Feingold, there has been public concern that food colorings may cause ADHD-like behavior in children. These concerns have led the FDA and other food safety authorities to regularly review the scientific literature, and led the UK FSA to commission a study by researchers at Southampton University of the effect of a mixture of the 'Southampton 6' and sodium benzoate (a preservative) on children in the general population who consumed them in beverages; the study published in 2007. The study found 'a possible link between the consumption of these artificial colours and a sodium benzoate preservative and increased hyperactivity' in the children; the advisory committee to the FSA that evaluated the study also determined that because of study limitations, the results could not be extrapolated to the general population, and further testing was recommended'.