Akuammicine

Akuammicine is an alkaloid found in Vinca minor and Aspidosperma. It is a μ-opioid receptor agonists while also agonizing (but to a much lower, clinically insignificant degree) the κ and δ-opioid receptors. Agonistic activity at both human variants of the σ-sigma receptors has been indicated but is not yet proven, so have possible mechanisms of action at the NMDA receptor (antagonist) and glycine receptor. Akuammicine is an alkaloid found in Vinca minor and Aspidosperma. It is a μ-opioid receptor agonists while also agonizing (but to a much lower, clinically insignificant degree) the κ and δ-opioid receptors. Agonistic activity at both human variants of the σ-sigma receptors has been indicated but is not yet proven, so have possible mechanisms of action at the NMDA receptor (antagonist) and glycine receptor.