Poly(A)-specific ribonuclease

2A1R, 2A1S, 3CTR507374108ENSG00000140694ENSG00000274829ENSMUSG00000022685O95453Q8VDG3NM_001134477NM_001242992NM_002582NM_028761NM_001358452NM_001358453NP_001127949NP_001229921NP_002573NP_083037NP_001345381NP_001345382Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.1whv: Solution structure of the RNA binding domain from hypothetical protein BAB233822a1r: Crystal structure of PARN nuclease domain2a1s: Crystal structure of native PARN nuclease domain Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits. Hereditary mutations in PARN lead to the bone marrow failure disease Dyskeratosis Congenita which is caused by defective telomerase RNA processing and degradation in patients.