Diffuse palmoplantar keratoderma

Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the palms and soles.see also Template:Congenital malformations and deformations of skin appendages, Template:Phakomatoses, Template:Pigmentation disorders, Template:DNA replication and repair-deficiency disorder Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the palms and soles. Autosomal recessive and dominant, X-linked, and acquired forms have all been described.:505:211 Clinically, three distinct patterns of palmoplantar keratoderma may be identified: diffuse, focal, and punctate.:505 Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life.:505 Restated, diffuse palmoplantar keratoderma is an autosomal dominant disorder in which hyperkeratosis is confined to the palms and soles. The two major types can have a similar clinical appearance: