Complement factor B

3HS0, 1DLE, 1Q0P, 1RRK, 1RS0, 1RTK, 2OK5, 2WIN, 2XWB, 2XWJ, 3HRZ62914962ENSG00000241534ENSG00000204359ENSMUSG00000090231P00751P04186NM_001710NM_001142706NM_008198NP_001701NP_001136178NP_032224Complement factor B is a protein that in humans is encoded by the CFB gene.1dle: FACTOR B SERINE PROTEASE DOMAIN1q0p: A domain of Factor B1rrk: Crystal Structure Analysis of the Bb segment of Factor B1rs0: Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)1rtk: Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid2ok5: Human Complement factor B Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.