Proto-oncogene tyrosine-protein kinase Src

1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ671420779ENSG00000197122ENSMUSG00000027646P12931P05480NM_005417NM_198291NM_001025395NM_009271NP_005408NP_938033NP_001020566NP_033297Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. This protein phosphorylates specific tyrosine residues in other tyrosine kinases.1a07: C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE)1a08: C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)1a09: C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine)1a1a: C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)1a1b: C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)1a1c: C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))1a1e: C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE)1bkl: SELF-ASSOCIATED APO SRC SH2 DOMAIN1bkm: COCRYSTAL STRUCTURE OF D-AMINO ACID SUBSTITUTED PHOSPHOPEPTIDE COMPLEX1f1w: SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN1f2f: SRC SH2 THREF1TRP MUTANT1fmk: CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC1hcs: NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX1hct: NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX1is0: Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor1kc2: structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide1ksw: Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP1nlo: STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE1nlp: STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE1nzl: Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI1nzv: Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA1o41: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300.1o42: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843.1o43: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129.1o44: Crystal structure of sh2 in complex with ru850521o45: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687.1o46: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.1o47: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.1o48: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.1o49: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493.1o4a: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197.1o4b: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876.1o4c: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.1o4d: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.1o4e: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299.1o4f: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073.1o4g: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59.1o4h: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072.1o4i: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219.1o4j: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24.1o4k: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN.1o4l: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2.1o4m: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID.1o4n: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID.1o4o: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE.1o4p: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791.1o4q: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256.1o4r: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78783.1p13: Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK)1prl: TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS1prm: TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS1qwe: C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP121qwf: C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL121rlp: TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS1rlq: TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS1sha: CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES1shb: CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES1shd: PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS1skj: COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX1spr: BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS1sps: BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS1srl: 1H AND 15N ASSIGNMENTS AND SECONDARY STRUCTURE OF THE SRC SH3 DOMAIN1srm: 1H AND 15N ASSIGNMENTS AND SECONDARY STRUCTURE OF THE SRC SH3 DOMAIN1y57: Structure of unphosphorylated c-Src in complex with an inhibitor1yi6: C-term tail segment of human tyrosine kinase (258-533)1yoj: Crystal structure of Src kinase domain1yol: Crystal structure of Src kinase domain in complex with CGP776751yom: Crystal structure of Src kinase domain in complex with Purvalanol A2bdf: Src kinase in complex with inhibitor AP234512bdj: Src kinase in complex with inhibitor AP234642h8h: Src kinase in complex with a quinazoline inhibitor2hwo: Crystal structure of Src kinase domain in complex with covalent inhibitor2hwp: Crystal structure of Src kinase domain in complex with covalent inhibitor PD1683932oiq: Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.2ptk: CHICKEN SRC TYROSINE KINASE2src: CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. This protein phosphorylates specific tyrosine residues in other tyrosine kinases. c-Src stands for 'cellular Src kinase' and should not be confused with 'C-terminal Src kinase' (CSK) which is an enzyme which phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity. Similarly, c-Src should not be mistaken for v-Src, a viral (hence the prefix v-) gene that shares similarity with c-Src and is also an oncogene, which can be found in Rous sarcoma virus. An elevated level of activity of c-Src tyrosine kinase is suggested to be linked to cancer progression by promoting other signals. Mutations in this gene could be involved in the malignant progression of colon cancer.