Large-cell lymphoma

The large-cell lymphomas have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that has turned cancerous. A large cell, in this context, has a diameter of 17 to 20 µm. Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.aggressive: Sézary disease The large-cell lymphomas have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that has turned cancerous. A large cell, in this context, has a diameter of 17 to 20 µm. Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas. Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase 'large-cell lymphoma' under 'Diffuse large B cell lymphoma'. Many other B-cell lymphomas feature large cells: Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway.This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously.The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes. Less commonly, a large-cell lymphoma may feature T cells. Anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves T cells. Of the large-cell T-cell lymphomas, it has the best prognosis.