In statistics, the Behrens–Fisher problem, named after Walter Behrens and Ronald Fisher, is the problem of interval estimation and hypothesis testing concerning the difference between the means of two normally distributed populations when the variances of the two populations are not assumed to be equal, based on two independent samples. In statistics, the Behrens–Fisher problem, named after Walter Behrens and Ronald Fisher, is the problem of interval estimation and hypothesis testing concerning the difference between the means of two normally distributed populations when the variances of the two populations are not assumed to be equal, based on two independent samples.