STAT6

1OJ5, 4Y5W, 4Y5U677820852ENSG00000166888ENSMUSG00000002147P42226P52633NM_001178078NM_001178079NM_001178080NM_001178081NM_003153NM_009284NP_001171549NP_001171550NP_001171551NP_001171552NP_003144NP_033310Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors. Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with: