MAPK8

1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4AWI, 4E73, 4G1W, 4HYS, 4HYU, 4IZY, 4L7F, 4QTD, 4UX9, 4YR8559926419ENSG00000107643ENSMUSG00000021936P45983Q91Y86NM_001323302NM_001323320NM_001323321NM_001323322NM_001323323NM_001323324NM_001323325NM_001323326NM_001323327NM_001323328NM_001323329NM_001323330NM_001323331NM_001310452NM_001310453NM_001310454NM_016700NP_001310251NP_001310252NP_001310253NP_001310254NP_001310255NP_001310256NP_001310257NP_001310258NP_001310259NP_001310260NP_620634NP_620637NP_001297381NP_001297382NP_001297383NP_057909Mitogen-activated protein kinase 8 (also known as JNK1) is an enzyme that in humans is encoded by the MAPK8 gene.1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP6001251uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP6001252b1p: inhibitor complex of JNK32exc: Inhibitor complex of JNK32g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6--4,5,6,7-tetrahydrothienopyridin-2-yl}-1-naphthalenecarboxamide2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Mitogen-activated protein kinase 8 (also known as JNK1) is an enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported. MAPK8 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.