Collagenous spherulosis

Collagenous spherulosis, or simple spherulosis, is a benign finding in breast pathology. It is almost always an incidental finding, though it is occasionally associated with calcifications, which may lead to a biopsy.Intermed. mag.High mag. Collagenous spherulosis, or simple spherulosis, is a benign finding in breast pathology. It is almost always an incidental finding, though it is occasionally associated with calcifications, which may lead to a biopsy. It is important to correctly identify, as it can be confused with atypical ductal hyperplasia, cribriform ductal carcinoma in situ (DCIS), and adenoid cystic carcinoma. Collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular eosinophilic material that classically is arranged like the spokes of a wheel ('radial spikes'). There is usually no mitotic activity, and two cells populations (epithelial & myoepithelial) are present, like in benign breast glands.