Chemical engineering is a branch of engineering that uses principles of chemistry, physics, mathematics, biology, and economics to efficiently use, produce, design, transport and transform energy and materials. The work of chemical engineers can range from the utilisation of nano-technology and nano-materials in the laboratory to large-scale industrial processes that convert chemicals, raw materials, living cells, microorganisms, and energy into useful forms and products. Chemical engineering is a branch of engineering that uses principles of chemistry, physics, mathematics, biology, and economics to efficiently use, produce, design, transport and transform energy and materials. The work of chemical engineers can range from the utilisation of nano-technology and nano-materials in the laboratory to large-scale industrial processes that convert chemicals, raw materials, living cells, microorganisms, and energy into useful forms and products. Chemical engineers are involved in many aspects of plant design and operation, including safety and hazard assessments, process design and analysis, modeling, control engineering, chemical reaction engineering, nuclear engineering, biological engineering, construction specification, and operating instructions. Chemical engineers typically hold a degree in Chemical Engineering or Process Engineering. Practising engineers may have professional certification and be accredited members of a professional body. Such bodies include the Institution of Chemical Engineers (IChemE) or the American Institute of Chemical Engineers (AIChE).A degree in chemical engineering is directly linked with all of the other engineering disciplines, to various extents. A 1996 British Journal for the History of Science article cites James F. Donnelly for mentioning an 1839 reference to chemical engineering in relation to the production of sulfuric acid. In the same paper however, George E. Davis, an English consultant, was credited for having coined the term. Davis also tried to found a Society of Chemical Engineering, but instead it was named the Society of Chemical Industry (1881), with Davis as its first Secretary. The History of Science in United States: An Encyclopedia puts the use of the term around 1890. 'Chemical engineering', describing the use of mechanical equipment in the chemical industry, became common vocabulary in England after 1850. By 1910, the profession, 'chemical engineer,' was already in common use in Britain and the United States. Chemical engineering emerged upon the development of unit operations, a fundamental concept of the discipline of chemical engineering. Most authors agree that Davis invented the concept of unit operations if not substantially developed it. He gave a series of lectures on unit operations at the Manchester Technical School (later part of the University of Manchester) in 1887, considered to be one of the earliest such about chemical engineering. Three years before Davis' lectures, Henry Edward Armstrong taught a degree course in chemical engineering at the City and Guilds of London Institute. Armstrong's course failed simply because its graduates were not especially attractive to employers. Employers of the time would have rather hired chemists and mechanical engineers. Courses in chemical engineering offered by Massachusetts Institute of Technology (MIT) in the United States, Owens College in Manchester, England, and University College London suffered under similar circumstances. Starting from 1888, Lewis M. Norton taught at MIT the first chemical engineering course in the United States. Norton's course was contemporaneous and essentially similar to Armstrong's course. Both courses, however, simply merged chemistry and engineering subjects along with product design. 'Its practitioners had difficulty convincing engineers that they were engineers and chemists that they were not simply chemists.' Unit operations was introduced into the course by William Hultz Walker in 1905. By the early 1920s, unit operations became an important aspect of chemical engineering at MIT and other US universities, as well as at Imperial College London. The American Institute of Chemical Engineers (AIChE), established in 1908, played a key role in making chemical engineering considered an independent science, and unit operations central to chemical engineering. For instance, it defined chemical engineering to be a 'science of itself, the basis of which is ... unit operations' in a 1922 report; and with which principle, it had published a list of academic institutions which offered 'satisfactory' chemical engineering courses. Meanwhile, promoting chemical engineering as a distinct science in Britain led to the establishment of the Institution of Chemical Engineers (IChemE) in 1922. IChemE likewise helped make unit operations considered essential to the discipline. In 1940s, it became clear that unit operations alone were insufficient in developing chemical reactors. While the predominance of unit operations in chemical engineering courses in Britain and the United States continued until the 1960s, transport phenomena started to experience greater focus. Along with other novel concepts, such as process systems engineering (PSE), a 'second paradigm' was defined. Transport phenomena gave an analytical approach to chemical engineering while PSE focused on its synthetic elements, such as control system and process design. Developments in chemical engineering before and after World War II were mainly incited by the petrochemical industry, however, advances in other fields were made as well. Advancements in biochemical engineering in the 1940s, for example, found application in the pharmaceutical industry, and allowed for the mass production of various antibiotics, including penicillin and streptomycin. Meanwhile, progress in polymer science in the 1950s paved way for the 'age of plastics'. Concerns regarding the safety and environmental impact of large-scale chemical manufacturing facilities were also raised during this period. Silent Spring, published in 1962, alerted its readers to the harmful effects of DDT, a potent insecticide. The 1974 Flixborough disaster in the United Kingdom resulted in 28 deaths, as well as damage to a chemical plant and three nearby villages. The 1984 Bhopal disaster in India resulted in almost 4,000 deaths. These incidents, along with other incidents, affected the reputation of the trade as industrial safety and environmental protection were given more focus. In response, the IChemE required safety to be part of every degree course that it accredited after 1982. By the 1970s, legislation and monitoring agencies were instituted in various countries, such as France, Germany, and the United States. Advancements in computer science found applications designing and managing plants, simplifying calculations and drawings that previously had to be done manually. The completion of the Human Genome Project is also seen as a major development, not only advancing chemical engineering but genetic engineering and genomics as well. Chemical engineering principles were used to produce DNA sequences in large quantities.