Contrast resolution is the ability to distinguish between differences in intensity in an image. The measure is used in medical imaging to quantify the quality of acquired images. It is a difficult quantity to define, because it depends on the human observer as much as the quality of the actual image. For example, the size of a feature affects how easily it is detected by the observer. Contrast resolution is the ability to distinguish between differences in intensity in an image. The measure is used in medical imaging to quantify the quality of acquired images. It is a difficult quantity to define, because it depends on the human observer as much as the quality of the actual image. For example, the size of a feature affects how easily it is detected by the observer.