Vinculin

1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90, 4LN2, 4LNP, 4PR9, 3JBK741422330ENSG00000035403ENSMUSG00000021823P18206Q64727NM_003373NM_014000NM_009502NP_003364NP_054706NP_033528In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.1qkr: CRYSTAL STRUCTURE OF THE VINCULIN TAIL AND A PATHWAY FOR ACTIVATION1rkc: Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)1rke: Human vinculin head (1-258) in complex with human vinculin tail (879-1066)1st6: Crystal structure of a cytoskeletal protein1syq: Human vinculin head domain VH1, residues 1-258, in complex with humantalin's vinculin binding site 1, residues 607-6361t01: Vinculin complexed with the VBS1 helix from talin1tr2: Crystal structure of human full-length vinculin (residues 1-1066)1u6h: Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)1xwj: Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969)1ydi: Human Vinculin Head Domain (VH1, 1-258) in Complex with Human Alpha-Actinin's Vinculin-Binding Site (Residues 731-760)1zvz: Vinculin Head (0-258) in Complex with the Talin Rod Residue 820-8441zw2: Vinculin Head (0-258) in Complex with the Talin Rod residues 2345-23691zw3: Vinculin Head (0-258) in Complex with the Talin Rod residues 1630-16522gdc: Structure of Vinculin VD1 / IpaA560-633 complex2gww: Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site (residues 602-633)2hsq: Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site 2 (residues 565-587) In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Discovered independently by Benny Geiger and Keith Burridge, its sequence is 20%-30% similar to α-catenin, which serves a similar function.