SPHK2

5684856632ENSG00000063176ENSMUSG00000057342Q9NRA0Q9JIA7NM_001204158NM_001204159NM_001204160NM_001243876NM_020126NM_001172561NM_020011NM_203280NP_001191087NP_001191088NP_001191089NP_001230805NP_064511NP_001166032NP_064395NP_975009Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene. Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. .