Arylsulfatase A

2HI8, 1AUK, 1E1Z, 1E2S, 1E33, 1E3C, 1N2K, 1N2L, 2AIJ, 2AIK41011883ENSG00000100299ENSMUSG00000022620P15289P50428NM_001362782NM_009713NP_001349711NP_033843Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.1auk: HUMAN ARYLSULFATASE A1e1z: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69S1e2s: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69A1e33: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT P426L1e3c: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69S SOAKED IN SYNTHETIC SUBSTRATE1n2k: Crystal structure of a covalent intermediate of endogenous human arylsulfatase A1n2l: Crystal structure of a covalent intermediate of endogenous human arylsulfatase A Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. A deficiency is associated with metachromatic leukodystrophy, an autosomal recessive disease. Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine.