LILRB1

1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO010859n/an/an/aQ8NHL6n/aNM_006669n/aNP_006660n/aLeukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.1g0x: CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF LIR-1 (ILT2)1p7q: Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor1ufu: Crystal structure of ligand binding domain of immunoglobulin-like transcript 2 (ILT2; LIR-1)1ugn: Crystal structure of LIR1.02, one of the alleles of LIR11vdg: Crystal structure of LIR1.01, one of the alleles of LIR1 Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. This article incorporates text from the United States National Library of Medicine, which is in the public domain.