Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. It is a chemical proteomic method for pharmacological discovery research. Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. It is a chemical proteomic method for pharmacological discovery research. Chemoproteomics can enable drug discovery. It is a method for identifying protein targets and potential off-target activity. A linker molecule connects a small molecule chemical probe (or library of chemical probes) with an analytically detectable bead or other agent for detection or separation.