Large cell neuroendocrine carcinoma of the lung

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large cell lung carcinoma.The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely 'combined large cell neuroendocrine carcinoma' (c-LCNEC).