KIR2DS4

3H8N3809n/aENSG00000275731ENSG00000273526ENSG00000275351ENSG00000274921ENSG00000277345ENSG00000276885ENSG00000284408ENSG00000274957ENSG00000276154ENSG00000284307ENSG00000283779ENSG00000274324ENSG00000221957ENSG00000274714ENSG00000274533ENSG00000276209ENSG00000276634ENSG00000276465ENSG00000274947ENSG00000283727ENSG00000283846ENSG00000276395ENSG00000276254ENSG00000275938ENSG00000284244ENSG00000284264ENSG00000283870ENSG00000283882n/aP43632Q8NHJ0n/aNM_012314NM_001281971NM_001281972n/aNP_001268900NP_001268901NP_036446NP_001268900.1n/aKiller cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene.1b6u: CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES1efx: STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW31im9: Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1 bound to its MHC ligand HLA-Cw41m4k: Crystal structure of the human natural killer cell activator receptor KIR2DS2 (CD158j)1nkr: INHIBITORY RECEPTOR (P58-CL42) FOR HUMAN NATURAL KILLER CELLS2dl2: KILLER IMMUNOGLOBULIN RECEPTOR 2DL22dli: KILLER IMMUNOGLOBULIN RECEPTOR 2DL2,TRIGONAL FORM Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This article incorporates text from the United States National Library of Medicine, which is in the public domain.