Phosphoinositide-dependent kinase-1

1H1W, 1OKY, 1OKZ, 1UU3, 1UU7, 1UU8, 1UU9, 1UVR, 1W1D, 1W1G, 1W1H, 1Z5M, 2BIY, 2PE0, 2PE1, 2PE2, 2R7B, 2VKI, 2XCH, 2XCK, 3H9O, 3HRC, 3HRF, 3ION, 3IOP, 3NAX, 3NAY, 3NUN, 3NUS, 3NUU, 3NUY, 3ORX, 3ORZ, 3OTU, 3PWY, 3QC4, 3QCQ, 3QCS, 3QCX, 3QCY, 3QD0, 3QD3, 3QD4, 3RCJ, 3RWP, 3RWQ, 3SC1, 4A06, 4A07, 4AW0, 4AW1, 4CT1, 4CT2, 4RQV, 4RRV, 4XX9, 5ACK, 5HO7, 5HO8, 5HKM, 5HNG517018607ENSG00000140992ENSMUSG00000024122O15530Q9Z2A0NM_001261816NM_002613NM_031268NM_001080773NM_001286662NM_011062NP_001248745NP_002604NP_112558NP_001074242NP_001273591NP_035192In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas.1h1w: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN1oky: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE1okz: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-011uu3: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY3335311uu7: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-21uu8: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-11uu9: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-31uvr: STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-81w1d: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1,3,4,5)-TETRAKISPHOSPHATE1w1g: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4-PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE1w1h: CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN1z5m: Crystal Structure Of N1-phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethylpropanediamide Complexed with Human PDK12biy: STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas. PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signaling.