NISCH

3P0C11188n/aENSG00000010322n/aQ9Y2I1n/aNM_001276293NM_001276294NM_007184n/aNP_001263222NP_001263223NP_009115n/aNischarin is a protein that in humans is encoded by the NISCH gene. Nischarin is a protein that in humans is encoded by the NISCH gene. This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. NISCH has been shown to interact with IRS4. This article incorporates text from the United States National Library of Medicine, which is in the public domain.