Tektin

Tektins are cytoskeletal proteins found in cilia and flagella as structural components of outer doublet microtubules. They are also present in centrioles and basal bodies. They are polymeric in nature, and form filaments.Tektin filaments are 2 to 3 nm diameter with two alpha helical segments. They have the consensus amino acid sequence of RPNVELCRD. Different types of tektins, designated as A (53 kDa), B (51 kDa), C (47 kDa) form dimers, trimers and oligomers in various combinations and are also associated with tubulin in the microtubule. Tektins A and B form heteropolymeric protofilaments whereas tektin C forms homodimers. Tektin filaments are present in a supercoiled state. This structure of tektins suggests that they are evolutionarily related to intermediate filaments.Tektins as integral components of microtubules are essential for their structural integrity. A mutation in the tektin-t genes may lead to defects in flagellar activity which could manifest, for instance, as immotility of sperm leading to male infertility. Tektins are thought to be involved in the assembly of the basal body.