Melatonin receptor 1A

454317773ENSG00000168412ENSMUSG00000054764P48039Q61184NM_005958NM_008639NP_005949NP_032665Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene. Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene. This gene encodes the MT1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.